Of course, the glue code also has runtime costs. JavaScript objects must be allocated and garbage collected, strings must be re-encoded, structs must be deserialized. Some of this cost is inherent to any bindings system, but much of it is not. This is a pervasive cost that you pay at the boundary between JavaScript and WebAssembly, even when the calls themselves are fast.
Real game engines use this pattern (or its 3D cousin, the Octree) for broad-phase collision detection: the quadtree quickly identifies candidate pairs, and a more expensive narrow-phase check tests the actual geometry.
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